Weiland was known for his flamboyant and chaotic onstage persona and also for constantly changing his appearance and vocal style, his use of a megaphone in concerts for vocal effect, and for his battles with substance abuse. Weiland was ranked in the Top 100 Heavy Metal vocalsists by Hit Parader Magazine (No. 57).
As a soloist he would release 12 Bar Blues (1998), "Happy" in Galoshes (2008) and Blaster (2015, with the Wildabouts).
In 2012, Weiland formed the backing band the Wildabouts. It was during this period that his health issues became noticeable and in December 2015, he died of an accidental drug overdose on his tour bus in Minnesota at the age of 48.